The Detroit Lions are coming off their best season in decades, winning the NFC North before heading to the NFC Championship Game. Fans are excited for the start of the 2024 NFL season as Detroit kicks off at home against the Rams. The Lions are 3.5-point favorites in the Week 1 NFL odds, with the over/under for total points at 51. That's a higher total than any game on the Week 1 NFL schedule, but which teams should you trust in your Week 1 NFL spread, over/under and money line picks?
Other NFL games with higher NFL Totals in NFL Las Vegas odds include Eagles vs. Packers (48.5), Colts vs. Texans (49) and Dolphins vs. Jaguars (49.5). Should you target any of these games for your Week 1 NFL bets? Before making any Week 1 NFL picks, you should check out the NFL spread, over/under and money line projections from SportsLine AI.
Built by SportsLine's data science team using cutting-edge artificial intelligence and machine learning technology, AI predictions and AI ratings are generated for each game. AI predictions are determined by statistically learning from historical data for each team and quantitatively rating the strength of the opponent's defense by assigning it a numerical value out of 100, called a Matchup Score.
Once a prediction is formulated, an AI rating is generated using the prediction, match score and market odds. For example, if a team has a weak defense, the prediction differs from the line and the odds are in your favour, you may see an A rating on an over bet.
Plus, SportsLine AI is SportsLine's first fully automated prediction model, which is continually updated with the latest available data to help you find the biggest discrepancies in lines. Last season, SportsLine's AI PickBot hit 1,674 4.5- and 5-star prop picks, a difference that anyone who's used the tool can attest to.
In Week 1, AI PickBot evaluated the NFL odds and provided NFL predictions for all 16 games. Here you can see only the AI predictions for Week 1 NFL schedule.
Top NFL AI picks for Week 1
After analyzing all the matches in Week 1, AI PickBot predicts the Broncos to cover a 5.5-point underdog against the Seahawks in a matchup that earned them an A-rated pick. This will be the first meeting between these two teams since 2022, when Seattle won 17-16 at home. AI PickBot predicted the Seahawks to win by less than 2 points in its Week 1 prediction and is anticipating a similar outcome this year.
Denver has won 13 of the last 19 meetings between these two teams, and the Broncos will be hoping to land their quarterback of the future. Rookie Bo Nix is coming off an outstanding final season at Oregon, throwing for 4,508 yards, 45 touchdowns and just three interceptions. He's one of the most experienced rookie quarterbacks of all time, which is one of the reasons Denver is underrated going into Week 1. See more football predictions and football picks for Week 1 from SportsLine.
How to make your NFL Week 1 picks
Additionally, AI PickBot generated eight A-rated picks for Week 1. Before you place any NFL bets for Week 1, you should check out AI PickBot's analysis, which you can find exclusively at SportsLine.
Who will win and cover each NFL game in Week 1, and which A-rated picks should you bet on? Visit SportsLine now for the top NFL picks against the spread, over-under and money line, all powered by the all-new SportsLine AI PickBot, which hit the mark on 1,674 top-rated picks last season.