South Korean researchers have found that ptosis is associated with COVID-19 vaccination, particularly the ChAdOx1 vaccine (AstraZeneca), and that Guillain-Barre syndrome/Miller-Fisher syndrome is associated with COVID-19 infection. reported to be associated with COVID-19 infection.1 Lead authors Jae Yong Han, MD, and Sunyeup Kim, MD, are from the Department of Ophthalmology, Institute of Vision, Yonsei University School of Medicine, Seoul, South Korea, and the Department of Medical AI, Sungkyunkwan University School of Medicine, Suwon, South Korea, respectively.
As the number of infected people and vaccinated people increases, an increasing number of ophthalmological adverse events, including neuro-ophthalmological adverse events, have been reported in patients with COVID-19 and vaccinated people.2-6 Other studies have reported that COVID-19 infection is associated with optic neuritis.7-9 and ophthalmoplegia was associated with third cranial nerve palsy or sixth cranial nerve palsy.10-16 Adverse events caused by vaccines have been reported.17–21 However, the researchers explained that it is unclear whether COVID-19 infection and vaccination are directly related to neuro-ophthalmological adverse events.
They conducted a large, national, population-based, retrospective cohort study to determine whether there is an association between COVID-19 infection, vaccination, and neuro-ophthalmological adverse events.
Approximately 8.5 million patients registered in South Korea’s National Health Insurance claims database are in one of three groups: controls, patients infected with COVID-19, and patients vaccinated against COVID-19. It was classified as Researchers aimed to estimate the incidence and hazard ratio (HR) of optic neuritis, papilledema, ischemic optic neuropathy, and neuro-ophthalmological adverse events in early (within 60 days) and late (within 61 days) 180 days) were analyzed separately. Third nerve palsy, fourth nerve palsy, sixth nerve palsy, facial nerve palsy, nystagmus, ptosis, blepharospasm, abnormal pupillary function, Guillain-Barre syndrome/Miller-Fisher syndrome.
association found
The authors reported that, with the exception of ptosis and Guillain-Barre syndrome/Miller-Fisher syndrome, neuro-ophthalmological adverse events did not show a significant increase after COVID-19, and their incidence was extremely low. . The incidence of early and late blepharoptosis was significantly higher in COVID-19 vaccinated patients compared to the control group (HR = 1.65 in early stage and 2.02 in late stage). The BNT162b2 (Pfizer-BioNTech) vaccine was associated with a lower risk of ptosis than the ChAdOx1 vaccine. Guillain-Barre syndrome/Miller-Fisher syndrome was significantly more common in the early stages of COVID-19 patients than in controls (HR = 5.97).
The authors concluded that “blepharoptosis is associated with COVID-19 vaccines, particularly the ChAdOx1 vaccine, and Guillain-Barre syndrome/Miller-Fisher syndrome is associated with COVID-19 infection.” In contrast, no association was found between other neuro-ophthalmological adverse events and COVID-19 infection or vaccination. These results may provide useful insights for the diagnosis and treatment of neuro-ophthalmological adverse events following COVID-19 infection. ”
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